2022

研究業績

Papers (English)

Original papers

1.Chino S, Mochizuki Y, Mizuma K, Ichikawa S, Miyazaki H, Hachiya R, Toyosaki E, Ota M, Fukuoka H, Yamochi T, Ono K, Shinke T. Transcranial Doppler for stratification of high-risk morphology of patent foramen ovale in patients with cryptogenic stroke. Heart Vessels 37:2119-2127, 2022

2.Hamaguchi T, Ono K, Yamada M. Transmission of cerebral β-Amyloidosis among individuals. Neurochem Res 47:2469-2477, 2022

3.Hikishima S, Sakai K, Akagi A, Yamaguchi H, Shibata S, Hayashi K, Nakano H, Kanemoto M, Usui Y, Taniguchi Y, Komatsu J, Nakamura-Shindo K, Nozaki I, Hamaguchi T, Ono K, Iwasa K, Yamada M. Deterioration after liver transplantation and transthyretin stabilizer administration in a patient with ATTRv amyloidosis with Leu58Arg (p.Leu78Arg) TTR variant. Intern Med 61:2347-2351, 2022

4.Ikeuchi T, Yano Y, Sato W, Morikawa F, Toru S, Nishimura C, Miyazawa N, Kuroha Y, Koike R, Tanaka S, Utsumi K, Kasuga K, Tokutake T, Ono K, Yano S, Naruse S, Yajima R, Hamano T, Yokoyama Y, Kitamura A, Kaneko E, Yamakado M, Nagao K. Development of a Novel Nutrition-Related Multivariate Biomarker for Mild Cognitive Impairment Based on the Plasma Free Amino Acid Profile. Nutrients 14:637, 2022

5.Ikeuchi T, Kanda M, Kitamura H, Morikawa F, Toru S, Nishimura C, Kasuga K, Tokutake T, Takahashi T, Kuroha Y, Miyazawa N, Tanaka S, Utsumi K, Ono K, Yano S, Hamano T, Naruse S, Yajima R, Kawashima N, Kaneko C, Tachibana H, Yano Y, Kato Y, Toue S, Jinzu H, Kitamura A, Yokoyama Y, Kaneko E, Yamakado M, Nagao K. Decreased circulating branched-chain amino acids are associated with development of Alzheimer’s disease in elderly individuals with mild cognitive impairment. Front Nutr 9:1040476, 2022

6.Iwasa K, Furukawa Y, Yoshikawa H, Yamada M, Ono K. CD59 Expression in Skeletal Muscles and Its Role in Myasthenia Gravis. Neurol Neuroimmunol Neuroinflamm 10:e200057, 2022

7.Kainuma M, Ouma S, Kawakatsu S, Iritani O, Yamashita KI, Ohara T, Hirano S, Suda S, Hamano T, Hieda S, Yasui M, Yoshiiwa A, Shiota S, Hironishi M, Wada-Isoe K, Sasabayashi D, Yamasaki S, Murata M, Funakoshi K, Hayashi K, Shirafuji N, Sasaki H, Kajimoto Y, Mori Y, Suzuki M, Ito H, Ono K, Tsuboi Y. An exploratory, open-label, randomized, multicenter trial of hachimijiogan for mild Alzheimer’s disease. Front Pharmacol 13:991982, 2022

8.Kasuga K, Kikuchi M, Tsukie T, Suzuki K, Ihara R, Iwata A, Hara N, Miyashita A, Kuwano R, Iwatsubo T, Ikeuchi T, Japanese Alzheimer’s Disease Neuroimaging Initiative. Different AT(N) profiles and clinical progression classified by two different N markers using total tau and neurofilament light chain in cerebrospinal fluid. BMJ Neurol Open 4:e000321, 2022

9.Kitahara K, Momo K, Nimura S, Okazaki K, Suzuki N, Kubota Y, Tsunoda T, Watanabe D, Mizuma K, Ono K, Sasaki T. A Case of Cerebral Infarction During Treatment With Rivaroxaban for Venous Thromboembolism. Am J Ther 29:e673-e676, 2022

10.Kuroda T, Honma M, Mori Y, Futamura A, Sugimoto A, Kasai H, Yano S, Hieda S, Kasuga K, Ikeuchi T, Ono K. White Matter Lesions May Aid in Differentiating Idiopathic Normal Pressure Hydrocephalus and Alzheimer’s Disease. J Alzheimers Dis 85:851-862, 2022

11.Kuroda T, Ono K, Honma M, Asano M, Mori Y, Futamura A, Yano S, Kanemoto M, Hieda S, Baba Y, Izumizaki M, Murakami H. Cerebral white matter lesions and regional blood flow are associated with reduced cognitive function in early-stage cognitive impairment. Front Aging Neurosci, in press.

12.Liu Y, Zhang Y, Thyreau B, Tatewaki Y, Matsudaira I, Takano Y, Hirabayashi N, Furuta Y, Hata J, Ninomiya T, Taki Y, Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Study Group. Altruistic Social Activity, Depressive Symptoms, and Brain Regional Gray Matter Volume: Voxel-Based Morphometry Analysis From 8,695 Old Adults. J Gerontol A Biol Sci Med Sci 77:1789-1797, 2022

13.Maki K, Ohara T, Hata J, Shibata M, Hirabayashi N, Honda T, Sakata S, Furuta Y, Akiyama M, Yamasaki K, Tatewaki Y, Taki Y, Kitazono T, Mikami T, Maeda T, Ono K, Mimura M, Nakashima K, Iga JI, Takebayashi M, Ninomiya T, Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study group. CKD, Brain Atrophy, and White Matter Lesion Volume: The Japan Prospective Studies Collaboration for Aging and Dementia. Kidney Med 5:100593, 2022

14.Mizuma K, Sugimoto A, Mochizuki Y, Shinke T, Ono K. A case report of platypnea-orthodeoxia syndrome: A rare condition found during diagnostic workup of a patient with embolic stroke of undetermined sources. eNeurologicalSci 26:100393, 2022

15.Momma Y, Tsuji M, Oguchi T, Ohashi H, Nohara T, Ito N, Yamamoto K, Nagata M, Kimura AM, Nakamura S, Kiuchi Y, Ono K. The Curcumin Derivative GT863 Protects Cell Membranes in Cytotoxicity by Aβ Oligomers. Int J Mol Sci, in press.

16.Mori M, Sakai K, Saito K, Nojima T, Mohri M, Matsubara K, Hayashi S, Yamada M. Hypertrophic Pachymeningitis with Characteristics of Both IgG4-related Disorders and Granulomatosis with Polyangiitis. Intern Med 61:1903-1906, 2022

17.Nakano H, Yamaguchi K, Hama N, Matsumoto Y, Shinohara M, Ide H. Relapsing Anti-MOG Antibody-associated Disease Following COVID-19 Vaccination: A Rare Case Report and Review of the Literature. Intern Med, in press.

18.Nakano H, Hamaguchi T, Ikeda T, Watanabe-Nakayama T, Ono K, Yamada M. Inactivation of seeding activity of amyloid β-protein aggregates in vitro. J Neurochem 160:499-516, 2022

19.Nakajima K, Saito S, Chen Z, Komatsu J, Maruyama K, Shirasaki N, Watanabe S, Inaki A, Ono K, Kinuya S. Diagnosis of Parkinson syndrome and Lewy-body disease using 123I-ioflupane images and a model with image features based on machine learning. Ann Nucl Med 36:765-776, 2022

20.Noguchi-Shinohara M, Ono K, Yuki-Nozaki S, Iwasa K, Yokogawa M, Komai K, Thyreau B, Tatewaki Y, Taki Y, Shibata M, Ohara T, Hata J, Ninomiya T, Yamada M. Association of the prefrailty with global brain atrophy and white matter lesions among cognitively unimpaired older adults: the Nakajima study. Sci Rep 12:12129, 2022

21.Noguchi-Shinohara M, Yuki-Nozaki S, Abe C, Mori A, Horimoto M, Yokogawa M, Ishida N, Suga Y, Ishizaki J, Ishimiya M, Nakamura H, Komai K, Nakamura H, Shibata M, Ohara T, Hata J, Ninomiya T, Yamada M, Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study group. Diabetes Mellitus, Elevated Hemoglobin A1c, and Glycated Albumin Are Associated with the Presence of All-Cause Dementia and Alzheimer’s Disease: The JPSC-AD Study. J Alzheimers Dis 85:235-247, 2022

22.Noguchi-Shinohara M, Hamaguchi T, Sakai K, Komatsu J, Iwasa K, Horimoto M, Nakamura H, Yamada M, Ono K. Effects of Melissa officinalis extract containing rosmarinic acid on cognition in older adults without dementia: a randomized controlled trial. J Alzheimers Dis, in press.

23.Noguchi-Shinohara M, Murakami H, Sakashita Y, Mori Y, Komatsu J, Muramatsu D, Hikishima S, Ono K. Plasma amyloid-β biomarkers are associated with Alzheimer’s disease comorbidity in Lewy body disease. Parkinsonism Relat Disord, in press.

24.Nozaki I, Hashiguchi A, Takashima H, Yamashita Y, Higashide T, Iwasa K, Ono K. Charcot-Marie-Tooth Disease with A Novel Variant in Gap Junction Protein Beta 1 Presenting with Visual Field Defects. Intern Med, in press.

25.Ohashi H, Tsuji M, Oguchi T, Momma Y, Nohara T, Ito N, Yamamoto K, Nagata M, Kimura AM, Kiuchi Y, Ono K. Combined Treatment with Curcumin and Ferulic Acid Suppressed the Aβ-Induced Neurotoxicity More than Curcumin and Ferulic Acid Alone. Int J Mol Sci 23:9685, 2022

26.Oki R, Izumi Y, Fujita K, Miyamoto R, Nodera H, Sato Y, Sakaguchi S, Nokihara H, Kanai K, Tsunemi T, Hattori N, Hatanaka Y, Sonoo M, Atsuta N, Sobue G, Shimizu T, Shibuya K, Ikeda K, Kano O, Nishinaka K, Kojima Y, Oda M, Komai K, Kikuchi H, Kohara N, Urushitani M, Nakayama Y, Ito H, Nagai M, Nishiyama K, Kuzume D, Shimohama S, Shimohata T, Abe K, Ishihara T, Onodera O, Isose S, Araki N, Morita M, Noda K, Toda T, Maruyama H, Furuya H, Teramukai S, Kagimura T, Noma K, Yanagawa H, Kuwabara S, Kaji R; Japan Early-Stage Trial of Ultrahigh-Dose Methylcobalamin for ALS (JETALS) Collaborators. Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial. JAMA Neurol 79:575-583, 2022

27.Sakai K, Noguchi-Shinohara M, Tanaka H, Ikeda T, Hamaguchi T, Kakita A, Yamada M, Ono K. Cerebrospinal Fluid Biomarkers and Amyloid-β Elimination from the Brain in Cerebral Amyloid Angiopathy-Related Inflammation. J Alzheimers Dis, in press.

28.Sakai K, Ishida C, Hayashi K, Tsuji N, Kannon T, Hosomichi K, Takei N, Kakita A, Tajima A, Yamada M. Familial idiopathic basal ganglia calcification with a heterozygous missense variant (c.902C>T/p.P307L) in SLC20A2 showing widespread cerebrovascular lesions. Neuropathology 42:126-133, 2022

29.Sakai K, Hayashi K, Saito Y, Kanemoto M, Nishino I, Yamada M, Ono K. Late-onset centronuclear myopathy caused by a heterozygous variant of DNM2 (c.1852G>C, p.A618P). Neurol Clin Neurosci 10:315-317, 2022

30.Sakashita Y, Nozaki I, Hamaguchi T, Kimura A, Shimohata T, Ono K. A case of autoimmune glial fibrillary acidic protein astrocytopathy presenting with magnetic resonance imaging mimics of multiple sclerosis. Clin Neurol Neurosurg 218:107272, 2022

31.Shigemoto Y, Matsuda H, Kimura Y, Chiba E, Ohnishi M, Nakaya M, Maikusa N, Ogawa M, Mukai Y, Takahashi Y, Sako K, Toyama H, Inui Y, Taki Y, Nagayama H, Ono K, Kono A, Sekiguchi K, Hirano S, Sato N. Voxel‐based analysis of age and gender effects on striatal [123I] FP‐CIT binding in healthy Japanese adults. Ann Nucl Med 36:460-467, 2022

32.Shima A, Sakai K, Yamashita F, Hamaguchi T, Kitamoto T, Sasaki M, Yamada M, Ono K. Vacuoles related to tissue neuron-astrocyte ratio and infiltration of macrophages/monocytes contribute to hyperintense brain signals on diffusion-weighted magnetic resonance imaging in sporadic Creutzfeldt-Jakob disease. J Neurol Sci, in press.

33.Shimizu A, Akagi A, Ishida C, Sakai K, Komai K, Kawamura M, Hasegawa M, Ikeuchi T, Yamada M. Frontotemporal lobar degeneration with unclassifiable 4-repeat tauopathy mimicking globular glial tauopathy. J Neuropathol Exp Neurol 81:581-584, 2022

34.Suda S, Katano T, Kitagawa K, Iguchi Y, Fujimoto S, Ono K, Kano O, Takekawa H, Koga M, Ihara M, Morimoto M, Yamagami H, Terasaki T, Yamaguchi K, Okubo S, Ueno Y, Ohara N, Kamiya Y, Takeuchi M, Yazawa Y, Terasawa Y, Doijiri R, Tsuboi Y, Sonoda K, Nomura K, Shimoyama T, Kutsuna A, Kimura K. Detection of Atrial Fibrillation Using Insertable Cardiac Monitors in Patients With Cryptogenic Stroke in Japan (the LOOK Study): Protocol for a Prospective Multicenter Observational Study. JMIR Res Protoc, in press.

35.Thyreau B, Tatewaki Y, Chen L, Takano Y, Hirabayashi N, Furuta Y, Hata J, Nakaji S, Maeda T, Noguchi-Shinohara M, Mimura M, Nakashima K, Mori T, Takebayashi M, Ninomiya T, Taki Y, Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Study Group. Higher-resolution quantification of white matter hypointensities by large-scale transfer learning from 2D images on the JPSC-AD cohort. Hum Brain Mapp 43: 3998-4012, 2022

36.Watanabe S, Nakajima K, Wakabayashi H, Yoneyama H, Yoshida S, Komatsu J, Konishi T, Inaki A, Kinuya S. Volumetric evaluation of 99mTc-pyrophosphate SPECT/CT for transthyretin cardiac amyloidosis: Methodology and correlation with cardiac functional parameters. J Nucl Cardiol 29:3102-3110, 2022

37.Watanabe-Nakayama T, Tsuji M, Umeda K, Oguchi T, Konno H, Noguchi-Shinohara M, Kiuchi Y, Kodera N, Teplow DB, Ono K. Structural Dynamics of Amyloid-β Protofibrils and Actions of Anti-Amyloid-β Antibodies as Observed by High-Speed Atomic Force Microscopy. Nano Lett, in press.

38.Yamaguchi H, Kawahara H, Kodera N, Kumaki A, Tada Y, Tang Z, Sakai K, Ono K, Yamada M, Hanayama R. Extracellular Vesicles Contribute to the Metabolism of Transthyretin Amyloid in Hereditary Transthyretin Amyloidosis. Front Mol Biosci 9:839917, 2022

39.Yoshida Y, Jin Z, Russo C, Homma S, Nakanishi K, Ito K, Mannina C, Elkind MSV, Rundek T, Yoshita M, DeCarli C, Wright CB, Sacco RL, Di Tullio MR. Subclinical left ventricular systolic dysfunction and incident stroke in the elderly: long-term findings from Cardiovascular Abnormalities and Brain Lesions. Eur Heart J Cardiovasc Imaging, in press.

40.Yoshikawa H, Adachi Y, Nakamura Y, Kuriyama N, Murai H, Nomura Y, Sakai Y, Iwasa K, Furukawa Y, Kuwabara S, Matsui M. Nationwide survey of Lambert-Eaton myasthenic syndrome in Japan. BMJ Neurol Open 4:e000291, 2022

41.Yoshikawa H, Adachi Y, Nakamura Y, Kuriyama N, Murai H, Nomura Y, Sakai Y, Iwasa K, Furukawa Y, Kuwabara S, Matsui M. Two-step nationwide epidemiological survey of myasthenia gravis in Japan 2018. PLoS One 17:e0274161, 2022

Reviews

1.Murakami K, Ono K. Interactions of amyloid coaggregates with biomolecules and its relevance to neurodegeneration. FASEB J 36:e22493, 2022

2.Saito S, Ono K, Tanaka M. Amyloid-β: Structure, Function, and Pathophysiological Significance in Neurodegenerative Diseases. Int J Mol Sci 23:10275, 2022

3.Watanabe-Nakayama T, Ono K. Acquisition and Processing of High-speed Atomic Force Microscopy Videos for Single Amyloid Aggregate Observation. Methods 197:4-12, 2022

4.Watanabe-Nakayama T, Ono K. Single-molecule observation of self-propagating amyloid fibrils. Microscopy (Oxf) 71:133-141, 2022

5.Yoshikawa H. Autoimmunity to acetylcholine receptor channels. Neurol Clin Neurosci, in press.

6.Yoshikawa H. Epidemiological study of myasthenia gravis in Japan. Clin Exp Neuroimmunol, in press.

Presentations (International meeting)

Invited lectures

1.Ono K. HMW Aβ oligomers are important targets for disease modifying approach of Alzheimer’s disease. Amyloid symposium ZOOMinar on “Molecular Bases of Proteinopathies”, WEB, February 28, 2022

2.Shinohara M, Yuki S, Ishida N, Ono K. Development of the German version of the C-ABC touch panel cognitive test and the relationship between social isolation and cognitive decline among older adults: Japan-Germany comparative study. 4th Japan-Germany symposium on Advanced Preventive Medicine 2022, WEB, February 4, 2022

Presentations

1.Futamura A, Kinno R, Hanazuka Y, Ochi R, Midorikawa A, Kitazawa S, Ono K, Kawamura M. Impairment of time perception in demented patients: linguistic assessment of past, present, and future. International Symposium on Chronogenesis: How the Mind Generates Time, Okinawa, November 23-24, 2022

2.Kimura A, Tsuji M, Yasumoto T, Mori Y, Oguchi T, Umino M, Tsuji Y, Umino A, Nishikawa T, Nakamura S, Inoue T, Kiuchi Y, Yamada M, Teplow D, Ono K. Myricetin prevents high molecular weight Aβ1-42 oligomer-induced neurotoxicity through antioxidant effects in cell membranes and mitochondria. Alzheimer’s Association International Conference 2022, San Diego, USA, July 31-August 2, 2022

3.Kinno R, Muragaki Y, Maruyama T, Tamura M, Tanaka K, Ono K, Sakai KL. Syntactic functions affected by both a glioma in the left internal capsule and structures in the right posterior insula. The 36th Annual Meeting of the Japan Neuroscience Society, Okinawa, June 30-July 3, 2022

4.Takahashi K, Komai K, Ishida C, Motozaki Y. Rehabilitation Prescription for Patients with Amyotrophic Lateral Sclerosis: Observations from a National Hospital in Japan. 16th ISPRM World Congress, Lisbon, July 3-7, 2022