Masahito Yamada, MD, PhD
Professor & Chair
Welcome to our homepage of the Department of Neurology and Neurobiology of Aging at Kanazawa University Graduate School of Medical Sciences / Neurological Clinic, Kanazawa University Hospital.
Our mission is to overcome neurological disorders through clinical, research, and educational activities. The research subjects include:
1.Amyloid, dementia, and age-related disorders. Clinical, epidemiological, and experimental studies are ongoing. We particularly focus on protein aggregation as pathogenesis of protein misfolding disorders to develop preventives/therapeutics for Alzheimer’s disease (AD), cerebral amyloid angiopathy (CAA), dementia with Lewy bodies (DLB)/Parkinson’s disease, and other aging-related disorders.
2.Prion diseases. Our laboratory is a center of clinical research on human prion diseases in Japan. Study on transmission of prion and prion-like proteins of neurodegenerative diseases is ongoing to elucidate the current status of transmission of prion and prion-like diseases and to develop molecular therapies targeting the transmission.
3.Neuroimmunology. Our research has focused on myasthenia gravis and other neuroimmunological disorders.
4.Imaging and functional analyses of brain. AD, DLB, CAA, and other age-related disorders have been studied with MRI, PET (FDG/amyloid), MIBG myocardial scintigraphy, MEG, and other modalities.
5.Population-based study on brain aging and dementia (“Nakajima Study”). The project is ongoing in the town of Nakajima, Nanao city, Ishikawa prefecture, Japan since 2006, in order to develop methods of early detection and prevention of cognitive impairment in the aging population. As preventive factors for cognitive impairment, we have focused on natural compounds in diets; the Nakajima Study identified preventive factors such as green tea, which lead us to basic studies with in vitro and in vivo AD models, and, then, to clinical/preventive interventions with the dietary compound.
I greatly appreciate collaborations with researchers all over the world. I encourage young people to join us and to extend clinical and research activities to overcome neurological disorders.