2021

研究業績

Papers (English)

Original papers

1.Amano R, Tsukada S, Kosuge S, Yano S, Ono K, Yoneda M, Taki K. Case Report: Paraneoplastic Hashimoto’s Encephalopathy Associated With Lymphomatosis Cerebri With Periodic Synchronous Discharges Resembling Creutzfeldt-Jakob Disease. Front Neurol 12:701178, 2021

2.Futamura A, Hieda S, Mori Y, Sugimoto A, Kasai H, Kuroda T, Yano S, Kasuga K, Murakami H, Ikeuchi T, Ono K. Cingulate Island Sign in Single Photon Emission Computed Tomography: Clinical Biomarker Correlations in Lewy Body Disease and Alzheimer’s Disease. J Alzheimers Dis 79:1003-1008, 2021

3.Futamura A, Hieda S, Mori Y, Kasuga K, Sugimoto A, Kasai H, Kuroda T, Yano S, Tsuji M, Ikeuchi T, Irie K, Ono K. Toxic amyloid-β42 conformer may accelerate the onset of Alzheimer’s disease in the preclinicalstage. J Alzheimers Dis 80:639-646, 2021

4.Hamaguchi T, Kim JH, Hasegawa A, Goto R, Sakai K, Ono K, Itoh Y, Yamada M. Exogenous Aβ seeds induce Aβ depositions in the blood vessels rather than the brain parenchyma, independently of Aβ strain-specific information. Acta Neuropathol Commun 9:151, 2021.

5.Hanada K, Yokoi K, Futamura A, Kinoshita Y, Sakamoto K, Ono K, Hirayama K. Numbsense of shape, texture, and objects after left parietal infarction: A case report. J Neuropsychol 15:204-214, 2021

6.Hanazuka Y, Futamura A, Hirata S, Midorikawa A, Ono K, Kawamura M. The Eyes Are More Eloquent Than Words: Anticipatory Looking as an Index of Event Memory in Alzheimer’s Disease. Front Neurol 12:642464, 2021

7.Hayashi K, Noguchi-Shinohara M, Sato T, Hosomichi K, Kannon T, Abe C, Domoto C, Yuki-Nozaki S, Mori A, Horimoto M, Yokogawa M, Sakai K, Iwasa K, Komai K, Ishimiya M, Nakamura H, Ishida N, Suga Y, Ishizaki J, Ishigami A, Tajima A, Yamada M. Effects of functional variants of vitamin C transporter genes on apolipoprotein E E4-associated risk of cognitive decline: The Nakajima study. PLoS One 16:e0259663, 2021

8.Hikishima S, Sakai K, Akagi A, Yamaguchi H, Shibata S, Hayashi K, Nakano H, Kanemoto M, Usui Y, Taniguchi Y, Komatsu J, Nakamura-Shindo K, Nozaki I, amaguchi T, Ono K, Iwasa K, Yamada M. Deterioration after liver transplantation and transthyretin stabilizer administration in a patient with ATTRv amyloidosis with Leu58Arg (p.Leu78Arg) TTR variant. Intern Med, in press

9.Honma M, Murakami H, Yabe Y, Kuroda T, Futamura A, Sugimoto A, Terao Y, Masaoka Y, Izumizaki M, Kawamura M, Ono K. Stopwatch training improves cognitive functions in patients with Parkinson’s disease. J Neurosci. Res 99:1325-1336, 2021

10.Ibrahim NF, Hamezah HS, Yanagisawa D, Tsuji M, Kiuchi Y, Ono K, Tooyama I. The effect of α-tocopherol, α- and γ-tocotrienols on amyloid-β aggregation and disaggregation in vitro. Biochem. Biophys Rep 28:101131, 2021

11.Iizuka N, Masaoka Y, Kubota S, Sugiyama H, Yoshida M, Yoshikawa A, Koiwa N, Honma M, Watanabe K, Kamijo S, Kamimura S, Ida M, Ono K, Izumizaki M. Entorhinal cortex and parahippocampus volume reductions impact olfactory decline in aged subjects. Brain Behav 11:e021152021, 2021

12.Inoue M, Noguchi S, Sonehara K, Nakamura-Shindo K, Taniguchi A, Kajikawa H, Nakamura H, Ishikawa K, Ogawa M, Hayashi S, Okada Y, Kuru S, Iida A, Nishino I. A recurrent homozygous ACTN2 variant associated with core myopathy. Acta Neuropathol 142:785-788, 2021

13.Ishida C, Takahashi K, Kato-Motozaki Y, Tagami A, Komai K. Effectiveness of levodopa in patients with multiple system atrophy and associated clinicopathological features. Intern Med 60:367-372, 2021

14.Ishida C, Kato-Motozaki Y, Noto D, Komai K, Hasegawa M, Ikeuchi T, Yamada M. An autopsy case of corticobasal degeneration with inferior olivary hypertrophy. Neuropathol 41:226-235, 2021

15.Ishida N, Tokumoto Y, Suga Y, Noguchi-Shinohara M, Abe C, Yuki-Nozaki S, Mori A, Horimoto M, Hayashi K, Iwasa K, Yokogawa M, Ishimiya M, Nakamura H, Komai K, Matsushita R, Ishizaki J, Yamada M. Factors associated with self-reported medication adherence in Japanese community-dwelling elderly individuals: The Nakajima Study. YAKUGAKU ZASSHI 141,751-759, 2021.

16.Kakinuma Y, Kimura T, Sakae Y, Kubota S, Ono K, Kinno R. Takotsubo syndrome associated with autoimmune limbic e 1 ncephalitis: A case report. BMC Cardiovasc Disord 21:86, 2021

17.Kashihara T, Nozaki I, Sakai K, Minamikawa J, Nakamura-Shindo K, Akagi A, Ozaki T, Nakano H, Shimizu A, Komatsu J, Shima K, Ikeda T, Samuraki-Yokohama M, Hamaguchi T, Iwasa K, Tanaka K, Yamada M. Recovery from multidisciplinary therapy-refractory anti-NMDA receptor encephalitis after over three years of mechanical ventilation. Clin Neurol Neurosurg 202:106477, 2021

18.Kimura A, Tsuji M, Yasumoto T, Mori Y, Oguchi T, Tsuji Y, Umino M, Umino A, Nishikawa T, Nakamura S, Inoue T, Yamada M, DB Teplow, Kiuchi Y, Ono K. Myricetin prevents high molecular weight Aβ1-42 oligomer-induced neurotoxicity through antioxidant effects in cell membranes and mitochondria. Free Radic Biol Med 171:232-244, 2021

19.Kokudai Y, Honma M, Masaoka Y, Yoshida M, Sugiyama H, Yoshikawa A, Koiwa N, Kubota S, Iizuka N, Wada S, Kamijo S, Yuki U, Yano S, Ida M, Ono K, Izumizaki M. Cascade process mediated by left hippocampus and left superior frontal gyrus affects relationship between aging and cognitive dysfunction. BMC Neurosci 22:75, 2021

20.Kumutpongpanich T, Ogasawara M, Ozaki A, Ishiura H, Tsuji S, Minami N, Hayashi S, Noguchi S, Iida A, Nishino I; OPDM_LRP12 Study Group, Mori-Yoshimura M, Oya Y, Ono K, Shimizu T, Kawata A, Shimohama S, Toyooka K, Endo K, Toru S, Sasaki O, Isahaya K, Takahashi MP, Iwasa K, Kira JI, Yamamoto T, Kawamoto M, Hamano T, Sugie K, Eura N, Shiota T, Koide M, Sekiya K, Kishi H, Hideyama T, Kawai S, Yanagimoto S, Sato H, Arahata H, Murayama S, Saito K, Hara H, Kanda T, Yaguchi H, Imai N, Kawagashira Y,Sanada M, Obara K, Kaido M, Furuta M, Kurashige T, Hara W, Kuzume D, Yamamoto M, Tsugawa J, Kishida H, Ishizuka N, Morimoto K, Tsuji Y, Tsuneyama A, Matsuno A, Sasaki R, Tamakoshi D, Abe E, Yamada S, Uzawa A. Clinicopathologic Features of Oculopharyngodistal Myopathy With LRP12 CGG Repeat Expansions Compared With Other Oculopharyngodistal Myopathy Subtypes. JAMA Neurol 78:853-863, 2021

21.Kuriki A, Ueno Y, Kamiya Y, Shimizu T, Doijiri R, Tateishi Y, Kikuno M, Shimada Y, Takekawa H, Yamaguchi E, Koga M, Ihara M, Ono K, Tsujino A, Hirata K, Toyoda K, Hasegawa Y, Hattori N, Urabe T. Atrial Septal Aneurysm may Cause In-Hospital Recurrence of Cryptogenic Stroke. J Atheroscler Thromb 28:514-523, 2021

22.Kuroda T, Honma M, Mori Y, Futamura A, Sugimoto A, Kasai H, Yano S, Hieda S, Kasuga K, Ikeuchi T, Ono K. White Matter Lesions May Aid in Differentiating Idiopathic Normal Pressure Hydrocephalus and Alzheimer’s Disease. J Alzheimers Dis, in press

23.Mannina C, Tugcu A, Jin Z, Russo C, Matsumoto K, Ito K, Homma S, Elkind MSV, Rundek T, Yoshita M, DeCarli C, Wright CB, Sacco RL, Di Tullio MR. Left atrial strain and subclinical cerebrovascular disease in older adults. JACC Cardiovasc Imaging 14:508-510, 2021

24.Masaoka Y, Sugiyama H, Yoshida M, Yoshikawa A, Honma M, Koiwa N, Kamijo S, Watanabe K, Kubota S, Iizuka N, Ida M, Ono K, Izumizaki M. Odors Associated With Autobiographical Memory Induce Visual Imagination of Emotional Scenes as Well as Orbitofrontal-Fusiform Activation. Front Neurosci 15:709050, 2021

25.Matsumoto M, Yamaguchi K, Fujisawa H. Intramedullary capillary hemangioma mimicking myelitis with longitudinally extensive spinal cord lesions. Neurol Clin Neurosci 9:111-113, 2021

26.Matsumura T, Saito T, Mori M, Kishida M, Tamagaki K, Yoshida Y, Ishikawa Y, Komai K, Goto K, Komori T. Infection control in the respiratory care of coronavirus disease-19 patients with neuromuscular diseases. Neurol Clin Neurosci 9:159-165, 2021

27.Matsumura T, Takada H, Kobayashi M, Nakajima T, Ogata K, Nakamura A, Funato M, Kuru S, Komai K, Futamura N, Adachi Y, Arahata H, Fukudome T, Ishizaki M, Suwazono S, Aoki M, Matsuura T, Takahashi MP, Sunada Y, Hanayama K, Hashimoto H, Nakamura H.A web-based questionnaire survey on the influence of coronavirus disease-19 on the care of patients with muscular dystrophy. Neuromuscul Disord 31:839-846, 2021

28.Miki A, Kinno R, Ochiai H, Kubota S, Mori Y, Futamura A, Sugimoto A, Kuroda T, Kasai H, Yano S, Hieda S, Kokaze A, Ono K. Sex Differences in the Relationship of Serum Vitamin B1 and B12 to Dementia Among Memory Clinic Outpatients in Japan. Front Aging Neurosci 13:667215, 2021

29.Mori M, Sakai K, Saito K, Nojima T, Mohri M, Matsubara K, Hayashi S, Yamada M. Hypertrophic pachymeningitis with characteristics of both IgG4-related disorders and granulomatous with polyangiitis. Intern Med, in press

30.Mori M, Sakai K, Tada Y, Nozaki I, Usui Y, Ichinose T, Tanaka S, Takahashi T, Nakada M, Yamada M. Late-onset acute disseminated encephalomyelitis followed by optic neuritis without anti-myelin oligodendrocyte glycoprotein antibodies: A biopsied case report. Neurol Sci 42:4731-4735, 2021

31.Mori Y, Tsuji M, Oguchi T, Kasuga K, Kimura A, Futamura A, Sugimoto A, Kasai H, Kuroda T, Yano S, Hieda S, Kiuchi Y, Ikeuchi T, Ono K. Serum BDNF as a Potential Biomarker of Alzheimer’s Disease: Verification Through Assessment of Serum, Cerebrospinal Fluid, and Medial Temporal Lobe Atrophy. Front Neurol 12:653267, 2021

32.Nakajima K, Okuda K, Komatsu J. What does diagnostic threshold mean? Deterministic and probabilistic considerations. J Nucl Cardiol 28:1702-1706, 2021

33.Nakano H, Hamaguchi T, Ikeda T, Watanabe-Nakayama T, Ono K, Yamada M. Inactivation of seeding activity of amyloid β-protein aggregates in vitro. J Neurochem, in press

34.Nakano H, Yamaguchi K, Kawabata K, Asakawa M, Matsumoto Y. Acute transverse myelitis after BNT162b2 vaccination against COVID-19: Report of a fatal case and review of the literature. J Neurol Sci 434:120102, 2021

35.Nakajima T, Sankai Y, Takata S, Kobayashi Y, Ando Y, Nakagawa M, Saito T, Saito K, Ishida C, Tamaoka A, Saotome T, Ikai T, Endo H, Ishii K, Morita M, Maeno T, Komai K, Ikeda T, Ishikawa Y, Maeshima S, Aoki M, Ito M, Mima T, Miura T, Matsuda J, Kawaguchi Y, Hayashi T, Shingu M, Kawamoto H. Cybernic treatment with wearable cyborg Hybrid Assistive Limb (HAL) improves ambulatory function in patients with slowly progressive rare neuromuscular diseases: a multicentre, randomised, controlled crossover trial for efficacy and safety (NCY-3001). Orphanet J Rare Dis 16:304, 2021

36.Noguchi-Shinohara M, Koike M, Morise H, Kudo K, Tsuchimine S, Komatsu J, Abe C, Kitagawa S, Ikeda Y, Yamada M. MEG activity of the dorsolateral prefrontal cortex during optic flow stimulations detects mild cognitive impairment due to Alzheimer’s disease. PLOS ONE 16:e0259677, 2021

37.Noguchi-Shinohara M, Yuki-Nozaki S, Abe C, Mori A, Horimoto M, Yokogawa M, Ishida N, Suga Y, Ishizaki J, Ishimiya M, Nakamura H, Komai K, Nakamura H, Shibata M, Ohara T, Hata J, Ninomiya T, Yamada M, JPSC-AD group. Diabetes mellitus, elevated hemoglobin A1c and glycated albumin are associated with the presence of all-cause dementia and Alzheimer’s disease: the JPSC-AD Study. J Alzheimer’s dis, in press

38.Sakai K, Ishida C, Hayashi K, Tsuji N, Kannon T, Hosomichi K, Takei N, Kakita A, Tajima A, Yamada M. Familial idiopathic basal ganglia calcification with a heterozygous missense variant (c.902C>T/p.P307L) in SLC20A2 showing widespread cerebrovascular lesions. Neuropathology, in press

39.Sakai K, Noguchi-Shinohara M, Ikeda T, Hamaguchi T, Ono K, Yamada M. Cerebrospinal fluid cytokines and metalloproteinases in cerebral amyloid angiopathy-related inflammation. Acta Neurol Scand 143:450-457, 2021

40.Sakashita Y, Matsubara T, Takata T, Tanei Z, Motoda A, Yamazaki M, Kawakami I, Sengoku R, Saito Y, Arai T, Yamada M, Murayama S. Lewy pathology of the submandibular gland in Lewy body disease: a report of autopsy. Neuropathology 41:476-483, 2021

41.Senda M, Ishii K, Ito K, Ikeuchi T, Matsuda H, Iwatsubo T, Iwata A, Ihara R, Suzuki K, Kasuga K, Ikari Y, Niimi Y, Arai H, Tamaoka A, Arahata Y, Itoh Y, Tachibana H, Ichimiya Y, Washizuka S, Odawara T, Ishii K, Ono K, Yokota T, Nakanishi A, Matsubara E, Mori H, Shimada H. A Japanese Multicenter Study on PET and Other Biomarkers for Subjects with Potential Preclinical and Prodromal Alzheimer’s Disease. J Prev Alzheimers Dis 8:495-502, 2021

42.Takahashi K, Murakami F, Komai K, Ishida C, Kato-Motozaki Y. Difference in the Care of Patients with Amyotrophic Lateral Sclerosis With and Without Intervention from the Palliative Care Team: Observations from a Center in Japan. Palliat Med Rep 2:201-206, 2021

43.Takahashi K, Murakami F, Komai K, Ishida C, Kato-Motozaki Y. Difference in the care of patients with amyotrophic lateral sclerosis with and without intervention from the Palliative Care Team: Observations from a Center in Japan. Palliat Med Rep 2:201-206, 2021

44.Wada S, Honma M, Masaoka Y, Yoshida M, Koiwa N, Sugiyama H, Iizuka N, Kubota S, Kokudai Y, Yoshikawa A, Kamijo S, Kamimura S, Ida M, Ono K, Onda H, Izumizaki M. Volume of the right supramarginal gyrus is associated with a maintenance of emotion recognition ability. PLoS One 16:e0254623, 2021

45.Walker JM, Richardson TE, Farrell K, Iida MA, Foong C, Shang P, Attems J, Ayalon G, Beach TG, Bigio EH, Budson A, Cairns NJ, Corrada M, Cortes E, Dickson DW, Fischer P, Flanagan ME, Franklin E, Gearing M, Glass J, Hansen LA, Haroutunian V, Hof PRHonig L, Kawas C, Keene CD, Kofler J, Kovacs GG, Lee EB, Lutz MI, Mao Q, Masliah E, McKee AC, McMillan CT, Mesulam MM, Murray M, Nelson PT, Perrin R, Pham T, Poon W, Purohit DP, Rissman RA, Sakai K, Sano M, Schneider JA, Stein TD, Teich AF, Trojanowski JQ, Troncoso JC, Vonsattel J-P, Weintraub S, Wolk DA, Woltjer RL, Yamada M, Yu L, White CL, Crary JF. Early selective vulnerability of the CA2 hippocampal subfield in primary age-related tauopathy. J Neuropathol Exp Neurol 80:102-111, 2021

46.Watanabe S, Nakajima K, Wakabayashi H, Yoneyama H, Yoshida S, Komatsu J, Konishi T, Inaki A, Kinuya S. Volumetric evaluation of 99m Tc-pyrophosphate SPECT/CT for transthyretin cardiac amyloidosis: Methodology and correlation with cardiac functional parameters Nucl Cardiol, in press

47.Wißfeld J, Nozaki I, Mathews M, Raschka T, Ebeling C, Hornung V, Brüstle O, Neumann H. Deletion of Alzheimer’s Disease-associated CD33 Results in an Inflammatory Human Microglia Phenotype. Glia 69:1393-1412, 2021 *These authors are equally contributed.

48.Yamamoto S, Noguchi-Shinohara M, Hamaguchi T, Yamada M, Kobayashi S. Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway. npj Science of Food 5:1, 2021

Reviews

1.Kinno R, Ono K. Takotsubo Syndrome: Optimizing Care with a Multidisciplinary Approach. J Multidiscip Healthc 14:2487-2499, 2021

2.Murakami H, Ono K, Shiraishi T, Umehara T, Omoto S, Iguchi Y. Correlations of cognitive domains with cerebrospinal fluid α-synuclein levels in patients with Parkinson’s disease. Front Aging Neurosci 12:616357, 2021

3.Ono K, Watanabe-Nakayama T. Aggregation and structure of amyloid β-protein. Neurochem Int 151:105208, 2021

4.Sakai K, Yamada M. Cerebral amyloid angiopathy-related inflammation and dementia. Clin Exp Neuroimmunol 12:101-106, 2021

5.Watanabe-Nakayama T, Ono K. Acquisition and processing of high-speed atomic force microscopy videos for single amyloid aggregate observation. Methods, in press

Presentations (International meeting)

Invited lectures

1.Ono K: HMW Aβ oligomers are important targets for disease modifying approach of Alzheimer’s disease. FASEB The Protein Aggregation Conference: Function, Dysfunction, and Disease. Virtual Conference, June 23-25, 2021

Presentations

1.Kanemoto M, Sotaro H, Ono K. IV lacosamide use in Showa University Hospital. 13th Asian & Oceanian Epilepsy Congress, Fukuoka, June 10-13, 2021

2.Kanemoto M, Ono K, Kato M. Transition of epilepsy patient to Neurology in Showa University, Japan. 34th International Epilepsy Congress, virtual congress, August 28- September 1, 2021

3.Kimura A, Yasumoto T, Mori Y, Oguchi T, Umino M, Umino A, Nakamura S, Inoue T, Yamada M, DB Teplow, Kiuchi Y, Tsuji M, Ono K. Myricetin prevents Aβ oligomers-induced neurotoxicity via cell membrane damage. 15th International Conference on Alzheimer’s & Parkinson’s Diseases, Virtual Conference, March 9-14, 2021

4.Kimura A, Kinno R, Tsuji M, Ono K. Effects of Vitamin B12 on cognitive function in elderly patients. Alzheimer’s Association International Conference AAIC2021, Denver, July 26-30, 2021

5.Komai K, Ishida C, Takahashi K, Tagami A, Motozaki Y. Prognosis of pathologically confirmed Japanese amyotrophic lateral sclerosis, a retrospective institute-based study. 73rd Annual meeting of AAN (American Academy of Neurology), San Francisco (WEB), April 17-23, 2021

6.Komai K, Ishida C, Takahashi K, Tagami A, Motozaki Y. Prognosis of pathologically confirmed Japanese amyotrophic lateral sclerosis, a retrospective hospital-based study. XXV World Congress of Neurology, Rome (WEB), October 3-7, 2021

7.Nakayama T, Tsuji M, Oguchi T, Ono K. Video imaging of structural dynamics of amyloid β protofibrils. Alzheimer’s Association International Conference AAIC2021, Denver, July 26-30, 2021