2013

研究業績

Papers (English)

Original papers

1. Di Tullio MR, Jin Z, Russo C, Elkind MS, Rundek T, Yoshita M, DeCarli C, Wright CB, Homma S, Sacco RL. Patent foramen ovale, subclinical cerebrovascular disease and ischemic stroke in a population-based cohort. J Am Coll Cardiol 62:35-41, 2013

2. Gong B, Pan Y, Vempati P, Zhao W, Knable L, Ho L, Wang J, Sastre M, Ono K, Pasinetti GM. Nicotinamide riboside restores cognition through an up-regulation of PGC-1α regulated BACE1 degradation and mitochondrial gene expression in Alzheimer’s mouse models. Neurobiol Aging 34:1581-1588, 2013

3. Hamaguchi T, Sakai K, Noguchi-Shinohara M, Nozaki I, Takumi I, Sanjo N, Sadakane A, Nakamura Y, Kitamoto T, Saito N, Mizusawa H, Yamada M. Insight into the frequent occurrence of dura mater graft-associated Creutzfeldt-Jakob disease in Japan. J Neurol Neurosurg Psychiatry 84:1171-1175, 2013

4. Higuma M, Sanjo N, Satoh K, Shiga Y, Sakai K, Nozaki I, Hamaguchi T, Nakamura Y,
Kitamoto T, Shirabe S, Murayama S, Yamada M, Mizusawa H. Relationships between clinicopathological features and cerebrospinal fluid biomarkers in Japanese patients with genetic prion desease. PLoS One 8:e60003, 2013

5. Iwasa K, Yoshikawa H, Samuraki M, Shinohara M, Hamaguchi T, Ono K, Nakamura H,
Yamada M. Myasthenia gravis: predictive factors associated with the synchronized elevation of anti-acetylcholine receptor antibody titer in Kanazawa, Japan. J Neuroimmunol (In Press)

6. Kobayashi A, Iwasaki Y, Otsuka H, Yamada M, Yoshida M, Matsuura Y, Mohri S, Kitamoto T. Deciphering the pathogenesis of sporadic Creutzfeldt-Jakob disease with codon 129 M/V and type 2 abnormal prion protein. Acta Neuropathol Commun 1:74, 2013

7. Kobayashi S, Yokoyama S, Maruta T, Negami M, Muroyama A, Mitsumoto Y, Iwasa K,
Yamada M, Yoshikawa H. Autoantibody-induced internalization of nicotinic acetylcholine receptor α3 subunit exogenously expressed in human embryonic kidney cells. J Neuroimmunol 2257:102-106, 2013

8. Kobayashi S, Yokoyama S, Maruta T, Muroyama A, Yoshikawa H, Mitsumoto Y. Attenuation of nicotine-evoked Ca2+ influx by antibody to the nicotinic acetylcholine receptor α3 subunits in human embryonic kidney cells. Adv Biosci Biotechnol 4:9-14, 2013

9. Komatsu J, Iwasa K, Yanase D, Yamada M. Inclusion body myopathy with Paget disease of the bone and frontotemporal dementia associated with a novel G156S mutation in the VCP gene. Muscle Nerve 48:995-996, 2013

10. Miyashita A, Koike A, Gyungah J, Wang L, Takahashi S, Matsubara E, Kawarabayashi T,
Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Ikeuchi T, Nishizawa M, Suga M, Kawase Y, Akatu H, Kosaka K, Yamamoto T, Imagawa M, Hamaguchi T, Yamada M, Morihara T, Takeda M, Takao T, Nakata K, Fujisawa Y, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa S, Yoshimoto S,
Nakagawa R, Kim J, Ki C, Won H, Na D, Seo S, Mook-Jung I, The Alzheimer disesase genetics Consortium, George-Hyslop P, Mayeux R, Haines JL, Pericak-Vance M, Yoshida M, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Kanazawa I, Ihara Y, Schellenberg GD, Farrer LA, Kuwano R. SORL1 is genetically associated with late-onset Alzheimer’s disease in Japanese, Koreans, and Caucasians. PLoS One 8:e58618, 2013

11. Miyoshi I, Fujimoto Y, Yamada M, Abe S, Zhao Q, Cronenberger C, Togo K, Ishibashi T,
Bednar MM, Kupiec JW, Binneman B. Safety and pharmacokinetics of PF-04360365 following a single-dose intravenous infusion in Japanese subjects with mild-to-moderate Alzheimer’s disease: a multicenter, randomized, double-blind, placebo-controlled, dose-escalation study. Int J Clin Pharmacol Ther 51:911-923, 2013

12. Negami M, Maruta T, Takeda C, Adachi Y, Yoshikawa H. Sympathetic skin response and heart rate variability as diagnostic tools for the differential diagnosis of Lewy body dementia and Alzheimer’s disease: a diagnostic test study. BMJ Open 3:e001796, 2013

13. Noguchi-Shinohara M, Yuki S, Dohmoto C, Ikeda Y, Samuraki M, Iwasa K, Yokogawa M,
Asai K, Komai K, Nakamura H, Yamada M. Differences in the prevalence of dementia and mild cognitive impairment and cognitive functions between early and delayed responders in a community-based study of the elderly. J Alzheimers Dis 37:691-698, 2013

14. Noto D, Sakuma H, Takahashi K, Saika R, Saga R, Yamada M, Yamamura T, Miyake S. Development of a culture system to induce microglia-like cells from haematopoietic cells. Neuropathol Appl Neurobiol (In Press)

15. Nozaki I, Kato-Motozaki Y, Ikeda T, Takahashi K, Tagami A, Ishida C, Komai K. Clinical features in association with neurodegenerative diseases and malignancies. Eur Neurol (In Press)

16. Nozaki I, Furukawa Y, Kato-Motozaki Y, Ikeda T, Takahashi K, Tagami A, Ishida C, Komai K. Neuroleptic malignant syndrome induced by combination therapy with tetrabenazine and tiapride in a Japanese patient with Huntington’s disease at terminal stage of recurrent breast cancer. Intern Med (In Press)

17. Oishi M, Hayashi Y, Kita D, Fukui I, Shinohara M, Heiss JD, Hamada J. Rapidly progressing monoparesis caused by Chiari malformation type I without syringomyelia. Surg Neurol Int 4:79, 2013

18. Ono K, Takasaki J, Takahashi R, Ikeda T, Yamada M. Effects of Anti-parkinsonian agents on
β-amyloid and α-synuclein oligomer formation in vitro. J Neurosci Res 91:1371-1381, 2013

19. Ono K, Takahasi R, Ikeda T, Mizuguchi M, Hamaguchi T, Yamada M. Exogenous amyloidogenic proteins function as seeds in amyloid β-protein aggregation. Biochim Biophys Acta Mol Basis Dis (In Press)

20. Russo C, Jin Z, Homma S, Elkind MS, Rundek T, Yoshita M, Decarli C, Wright CB, Sacco RL,
Di Tullio MR. Subclinical left ventricular dysfunction and silent cerebrovascular disease the cardiovascular abnormalities and Brain Lesions (CABL) Study. Circulation 128:1105-1111, 2013

21. Russo C, Jin Z, Liu R, Iwata S, Tugcu A, Yoshita M, Homma S, Elkind MS, Rundek T,
Decarli C, Wright CB, Sacco RL, Di Tullio MR. LA volumes and reservoir function are associated with subclinical cerebrovascular disease: the CABL (Cardiovascular Abnormalities and Brain Lesions) study. JACC Cardiovasc Imaging 6:313-323, 2013

22. Sakai K, Hamaguchi T, Noguchi-Shinohara M, Nozaki I, Takumi I, Sanjo N, Nakamura Y, Kitamoto T, Saito N, Mizusawa H, Yamada M. Graft-related disease progression in dura mater graft-associated Creutzfeldt-Jakob disease: a cross-sectional study. BMJ Open 3:e003400, 2013

23. Takamori M, Nakamura T, Motomura M. Antibodies against Wnt receptor of muscle-specific tyrosine kinase in myasthenia gravis. J Neuroimmunol 254:183-186, 2013

24. Takamura Y*, Ono K*, Matsumoto J, Yamada M, Nishijo H. Effects of the neurotrophic agent T-817MA on oligomeric amyloid β-induced deficits in long-term potentiation in the hippocampal CA1 subfield. Neurobiol Aging 91:1371-1381, 2013 *equally contributed.

25. Wang J, Zhao Z, Lin E, Zhao W, Qian X, Freire D, Bilski AE, Cheng A, Vempati P, Ho L, Ono K, Yamada M, Pasinetti GM. Unintended effects of cardiovascular drugs on the pathogenesis of Alzheimer’s disease. PLoS One 8:e65232, 2013

Reviews

1. Yamada M. Brain hemorrhages in cerebral amyloid angiopathy. Semin Thromb Hemost 39:955-962, 2013

Invited lectures

1. Hamaguchi T. Propagation of cerebral β-amyloidosis. Asian Pacific Prion Symposium 2013, Sasebo, July 21-22, 2013

2. Ono K. Vitamin A, Phenolic Compounds and Alzheimer’s disease. Conference on Healthy Aging in Asia, Singapore, March 4-5, 2013

3. Yamada M. Cerebral amyloid angiopathy (CAA) and development of auti-Aβ aggregation therapies. The Stroke Resarch Meeting, Massachusetts General Hospital, Boston, July 12, 2013

4. Yamada M. Phenolic compounds with anti-aggregation effects on Aβ as preventives and therapeutics for Alzheimer’s disease. Alzheimer’s Association International Conference 2013, Ancillary Breakfast Workshop, Boston, July 17, 2013

5. Yoshikawa H. Corrent usage of prograf in Japan. Lecture at Samusung Medical Center, Seoul, November 22, 2013

6. Yoshikawa H. Corrent usage of prograf in Japan. Lecture at Serevrance Hospital, Seoul, November 22, 2013

7. Yoshikawa H. The current concept of therapy for myasthenia gravis in Japan. 2013 Annual Meeting of Korean Society of Neuromuscular Disorder. Key note lecture, Seoul, November 23, 2013

Presentations

1. Adachi Y, Yoshikawa H, Diverse student counseling systems in Japanese universities: a comparison with the U.S. system. American College Health Association 2013 Annual Meeting, Boston, May 28-June 1, 2013

2. Fujita K, Harada M, Uyama N, Sasaki M, Iwasaki Y, Satoh K, Sanjo N, Takao M, Hamaguchi T, Mizusawa H, Yamada M. Thin-slice diffusion-weighted imaging and arterial spin labeling for the diagnosis of Creutzfeldt-Jakob disease. Asian Pacific Prion Symposium 2013, Sasebo, July 21-22, 2013

3. Hamaguchi T, Sakai K, Noguchi-Shinohara M, Nozaki I, Takumi I, Sanjo N, Nakamura Y, Kitamoto T, Saito N, Mizusawa H, Yamada M. Comparison of dura mater graft-associated Creutzfeldt-Jakob disease between Japan and Other countries. Asian Pacific Prion Symposium 2013, Sasebo, July 21-22, 2013

4. Hizume M, Sanjo N, Nakamura Y, Kitamoto T, Yamada M, Hamaguchi T, Moriwaka F, Aoki M, Kuroiwa Y, Nishizawa M, Takeda M, Inuzuka T, Abe K, Murai H, Murayama S, Satoh K, Harada M, Saito N, Takumi I, Mizusawa H. Human prion disease in Japan: a prospective surveillance from 1999. Asian Pacific Prion Symposium 2013, Sasebo, July 21-22, 2013

5. Ishida N, Kobayashi E, Matsushita R, Komai K. Effect of food on pharmacokinetics of 3,4-Diaminopyridine in rats and healthy volunteers. 21th World Congress of Neurology (WCN2013), Vienna, September 21-26, 2013

6. Kobayashi A, Iwasaki Y, Otsuka H, Yamada M, Yoshida M, Matsuura Y, Mohri S, Kitamoto T. Revision of sporadic Creutzfeldt-Jakob disease with MV2 prions. Asian Pacific Prion Symposium 2013, Sasebo, July 21-22, 2013

7. Komai K, Ishida C, Takahashi K, Furukawa Y, Motozaki Y, Ikeda T, Nozaki I, Tagami, A. Hypercapnic respiratory failure in patients with progressive supranuclear palsy. 21th World Congress of Neurology (WCN2013), Vienna, September 21-26, 2013

8. Mizusawa H, Nakamura Y, Takumi I, Yamada M. CJD Surveillance in Japan. European CJD Surveillance Network, Oslo, June 6-7, 2013

9. Nicoll J, Sakai K, Boche D, Love S. Cerebral amyloid angiopathy-associated and apolipoprotein E accumulation after Aβ immunotherapy for Alzheimer’s disease. AAIC 2013, Boston, July13-18, 2013

10. Nozaki I, Kato-Motozaki Y, Ikeda T, Takahashi K, Tagami A, Ishida C, Komai K. Clinical characteristics in association with neurodegenerative diseases and cancer. World Congress of Neurology 2013, Vienna, September 21-26, 2013

11. Ono K, Li L, Takamura Y, Yoshiike Y, Ikeda T, Takasaki J-I, Nishijo H, Takashima A,
Teplow DB, Zagorski MG, Yamada M. Phenolic compounds prevent β-amyloid-protein oligomerization and synaptic dysfunction by site-specific binding. Alzheimer’s Association International Conference on Alzheimer’s Disease 2013, Boston, July 13-18, 2013

12. Russo C, Jin Z, Homma S, Wright CB, Rundek T, Yoshita M, DeCarli C, Elkind MSV, Sacco RL,
Di Tullio MR. Association of left ventricular global longitudinal strain with silent brain infarcts in a community-based cohort with normal ejection fraction. American Clollege of Cardiology 62nd Annual Scientific Session, San Francisco, March 9-11, 2013

13. Sakai K, Boche D, Love S, Nicoll J. Cerebral amyloid angiopathy-associated vasculopathy and apolipoprotein E accumulation after Aβ immunotherapy for Alzheimer’s disease. Alzheimer’s Research UK Conference 2013, Belfast, March 11-12, 2013

14. Sakai K, Boche D, Love S, Nicoll J. Aquaporin 4 protein expression after immunotherapy for Alzheimer’s disease. 11th Annual Southampton Neuroscience Group (SoNG) Meeting, Southampton, September 19, 2013

15. Takahashi K. Usefulness of glucose transpoter-5, MHC class II, CD68, and Iba-1 as microglia markers. The XI European Meeting on Glial Cells in Health and Disease, Berlin, July 3-6, 2013

16. Takahashi K, Komai K, Ishida C, Nozaki I, Ikeda T, Motozaki Y. Antiphospholipid antibodies in patients with multiple sclerosis or neuromyelitis optica in Ishikawa prefucture, Japan. XXI World congress of Neurology, Vienna, September 21-26, 2013

17. Tugcu A, Russo C, Jin Z, Yoshita M, Homma S, Elkind M, Rundek T, DeCarli C, Wright C,
Sacco R, Di Tullio M. Global left atrial deformation is associated with silent brain infarcts: The cardiovascular abnormalities and brain lesions (CABL) study. American Clollege of Cardiology 62nd Annual Scientific Session, San Francisco, March 9-11, 2013

18. Yoshita M, Tsuji S, Yokoyama K. Differential diagnosis of AD using PIB and FDG-PET in a memory clinic. 21st World Congress of Neurology, Vienna, September 21-26, 2013

19. Yamamoto M, Yoshikawa H, Adachi Y, Kanoh A, Isomura Y, Sado T, Nishio A.“Promotion for Japanese university students to consider life planning: career life and family life.”2013 the 29th International Congress of the Medical Women’s International Association, Ewha Womans University, Seoul, July31-August 3, 2013